Week of January 27 Regulatory Intelligence Recap

Trade Press and Regulatory Summary:

• "FDA approval of ZYN nicotine pouches signals growth potential for UK market" (Vape Business) - The FDA's authorization of ZYN nicotine pouches has significant implications for future market growth in the UK.

• "Altria says smoke-free targets under threat from illicit vapes" (Vape Business) - Altria reviews its 2028 smoke-free product goals due to challenges from illicit vaping products. (analysis below)

• "Federal Appellate Court Agrees that FDA Cannot Regulate 'Premium Cigars'" (Tobacco Law Blog) - Federal court ruling limits FDA's authority to regulate premium cigars, marking another legal victory for the cigar industry.

• "E-Cigarette Falsehoods from the President of the American Medical Association" (Tobacco Truth Blog) - A critique of statements made by the AMA president regarding e-cigarettes.

• "Illicit Chinese Vapes Trafficked over Border Raise GOP Alarm" (Breitbart) - Report on Republican concerns about illicit Chinese e-cigarettes entering the US market under the Biden administration.

Publications Summary:

• Hartmann-Boyce J, et al. Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. 2025;1:CD010216 - Updated Cochrane review examining the effectiveness of e-cigarettes for smoking cessation.

• Baker TB, et al. BENEFICIAL AND HARMFUL TOBACCO USE TRANSITIONS ASSOCIATED WITH ENDS IN THE US. Am J Prev Med. 2025 - Analysis of transitions between different tobacco products associated with e-cigarette use.

• Pierce JP, et al. Electronic cigarettes and subsequent cigarette smoking in young people: A systematic review. Addiction. 2025 - Systematic review examining the relationship between youth e-cigarette use and subsequent smoking.

• Erythropel HC, et al. Assessing the impact of device parameters on electronic cigarette aerosol dynamics. Sci Total Environ. 2025;964:178583 - Study evaluating how different device characteristics affect e-cigarette aerosol formation and behavior.

• Pisinger C, et al. Evidence update on the cancer risk of vaping e-cigarettes: A systematic review. Tob Induc Dis. 2025 - Comprehensive review of current evidence regarding potential cancer risks associated with e-cigarette use.

Clinical Trials:

• "Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers" (NCT06804109) - Study examining effects of vagus nerve stimulation on cognitive function in young adult e-cigarette users.

• "The Abuse Liability of a Novel Heated Tobacco Product (IQOS)" (NCT05499377) - Investigation of addiction potential of IQOS heated tobacco products.

• "Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace" (NCT05110872) - Study examining how flavor restrictions affect tobacco product purchasing behavior.

• "COMET Study 1: Filter Ventilated Cigarette Substitution in the ETM" (NCT03306173) - Research on how cigarette filter ventilation affects consumer behavior and product use.